MOLECULAR LANDSCAPES BY DAVID S. GOODSELL

RecA and DNA

Acknowledgement: Illustration by David S. Goodsell, RCSB Protein Data Bank. doi: 10.2210/rcsb_pdb/goodsell-gallery-038

Recent work has shown that RecA protein (in turquoise) associates with DNA and forms a long, thin filament that stretches through a cell, providing a scaffold to assist with the pairing of homologous strands during DNA repair. Here, several sites in the DNA are temporarily pairing with the RecA DNA filament as the filament searches for an exact pairing.

Read more about the work in:

Wiktor J, Gynnå AH, Leroy P, Larsson J, Coceano G, Testa I, Elf J. (2021) RecA finds homologous DNA by reduced dimensionality search. Nature 597:426-429.

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